- PRODUCT NAME:Cagrilintide
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Items |
Specification |
Result |
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1 |
Appearaitee/Colors |
White or almost white powder |
White powder |
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2 |
Solubility |
Soluble in water |
Conforms |
|
3 |
Water Content (K.F) |
≤8.0% |
6.2% |
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4 |
Acetic Acid (By HPLC) |
≤8.0% |
4.5% |
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5 |
Trifluoroacetic acid |
≤0.5% |
0.1% |
|
6 |
Peptide Purity (By HPLC) |
≥98.0% |
99.5% |
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7 |
Related Substance (By HPLC) |
Total Impurities≤2.0% |
0.5% |
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Largest Single Impurity≤1.0% |
0.2% |
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|
8 |
Peptide Content |
≥85.0% |
88.9% |
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9 |
Organic solvent residue |
Acetonitrile≤0≥041 % |
Conforms |
|
Dichloromethane≤0.060% |
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N, N-Dimethylformainide≤0.088% |
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10 |
Bacterial Endotoxins |
≤10 EU/mg |
Conforms |
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11 |
Microbial Limits |
IAMC≤lOOcfu/g |
Conforms |
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TYMC≤100cfu/g |
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Storage
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Preserve in an air tight container, protected from light at a temperature of -15℃~25°C |
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Conclusion |
The product tested Conform with In- house standar |
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Remark |
It is only supplied as chemical product |
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1.What is Cagrilintide?
Cagrilintide is a novel long-acting acylated amylin analog that functions as a non-selective agonist for both the amylin receptor (AMYR) and the calcitonin G protein-coupled receptor (CTR).
2.How it Works?
Cagrilintide (GLP-1) is an incretin hormone used to treat type 2 diabetes. It works by mimicking the natural GLP-1 hormone in the body, helping to regulate blood sugar levels. However, like many protein and peptide-based drugs, Cagrilintide is susceptible to enzymatic degradation in the body, which limits its stability and bioavailability.
To enhance the stability and extend the half-life of Cagrilintide, scientists have developed a technique known as PEGylation. Specifically, this involves attaching polyethylene glycol (PEG) molecules to Cagrilintide. This modification increases the molecular size of Cagrilintide, reducing its clearance rate by the kidneys and prolonging its presence in the body.
Other methods to improve the stability of Cagrilintide include the use of DPP-4 inhibitors (such as sitagliptin) to inhibit the enzyme that breaks down GLP-1, or the development of new GLP-1 receptor agonists that are more resistant to degradation by DPP-4 enzymes.
3.Benefits and Uses
Cagrilintide has demonstrated significant potential in reducing body weight and decreasing food intake. Its promising effects in obesity research highlight its potential as a therapeutic option for weight management.
4.Q&A
Q:Does the company accept sample orders?
A:Yes, our company accepts sample orders.
Q:What is the minimum order quantity for the company?
A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.
Q:How to ensure the quality of goods?
A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.
Q:Can we see the product quality before the order is shipped?
A:Of course, we always provide a relative Batach (s) 'COA before shipping.
Q:How will you deliver the goods?
A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.
