1.What is Mirabegron?

Mirabegron is a β3-adrenergic receptor agonist, not a β2-adrenergic receptor agonist. It functions by stimulating the β3-adrenergic receptors, which helps to relax the bladder smooth muscle. This action makes it effective in treating symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence.

 

2.How it Works?

1. Selective Agonism of β3-Adrenergic Receptors: Mirabegron works by stimulating β3-adrenergic receptors, which promotes the relaxation of bladder smooth muscle. This action reduces the overactivity of the bladder muscle, thereby increasing bladder capacity and tolerance.

2. Inhibition of Adenylate Cyclase: In addition to its direct action on β3-adrenergic receptors, Mirabegron also inhibits the activity of adenylate cyclase. This inhibition leads to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels, further promoting the relaxation of bladder smooth muscle.

3. Reduction of Bladder Overactivity: Through the mechanisms described above, Mirabegron effectively alleviates symptoms such as urgency urinary incontinence, urgency, and frequency in patients. It improves the control over urination and enhances the quality of life.

3.Benefits and Uses

1. Improving Bladder Function: Mirabegron extended-release tablets selectively stimulate the β3-adrenergic receptors in the bladder, causing relaxation of the detrusor muscle. This promotes bladder filling, increases urine storage capacity, and effectively reduces the frequency of urination.

2. Relieving Urinary Frequency and Urgency: By inducing relaxation of the bladder smooth muscle, Mirabegron extended-release tablets alleviate the common symptoms of overactive bladder (OAB), such as urinary frequency and urgency, thereby reducing patient discomfort.

3. Treating Urinary Incontinence: While treating overactive bladder, Mirabegron extended-release tablets also significantly improve symptoms of urgency urinary incontinence, enhancing the quality of life for patients.

4. Good Cardiac Safety Profile: Mirabegron extended-release tablets have minimal impact on the heart during the treatment of overactive bladder, demonstrating a good cardiac safety profile and making them suitable for long-term use.

5. Treating Other Related Symptoms: In addition to overactive bladder, Mirabegron extended-release tablets can also be used to manage symptoms such as urinary frequency and urgency caused by benign prostatic hyperplasia, as well as conditions like uterine bleeding and promoting bowel movements.

4.Q&A

Q:Does the company accept sample orders?

A:Yes, our company accepts sample orders.

Q:What is the minimum order quantity for the company?

A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.

Q:How to ensure the quality of goods?

A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.

Q:Can we see the product quality before the order is shipped?

A:Of course, we always provide a relative Batach (s) 'COA before shipping.

Q:How will you deliver the goods?

A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.

5.Factory View