Retatrutide is a new entrant in the rapidly expanding field of anti obesity peptides. It is called GGG tri agonist. This means that retatrutide works on all intestinal insulinotropic receptors (including GLP-1 and GIP) as well as the glucagon receptor itself. Studies have shown that retatrutide may be the most effective weight loss peptide developed to date, with some studies indicating a rapid and sustained weight loss response of up to 24% of total body weight. Retatrutide is believed to promote weight loss by increasing and decreasing energy expenditure. It achieves the former by acting on glucagon receptors, while the latter is achieved through central and peripheral appetite control.