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Troxerutin
Troxerutin
CAS No.:7085-55-4
Molecular Formula:C33H42O19
Molecular Weight:742.67
PRODUCT NAME:Troxerutin

Troxerutin is a bioflavonoid derivative that is commonly used in pharmaceuticals and nutraceuticals due to its potential health benefits, particularly in managing venous disorders. It's typically available in different forms, including powders, tablets, capsules, or creams. As of my last update in January 2022, Troxerutin in powder form is used as an active pharmaceutical ingredient (API) for various medicinal products, especially those targeting circulatory system-related conditions.

Here is a general product description for Troxerutin powder as an API:

Product Name: Troxerutin Powder Chemical Formula: C33H42O19 Molecular Weight: Approximately 742.68 g/mol Category: Flavonoid derivative, often classified as a bioflavonoid Source: Troxerutin is a naturally occurring flavonoid found in certain plants, including the Japanese pagoda tree (Sophora japonica).

Mechanism of Action: Troxerutin is known for its venotonic and vasoprotective properties. It strengthens blood vessels, reduces capillary permeability, and exhibits antioxidant effects. Troxerutin primarily acts by improving blood flow, reducing inflammation, and protecting blood vessels, which can be beneficial in conditions like chronic venous insufficiency, hemorrhoids, and other venous disorders.

Indications: Troxerutin is often used in the formulation of medications or supplements targeting venous disorders, such as chronic venous insufficiency, varicose veins, venous ulcers, and hemorrhoids.

Dosage Form: Troxerutin powder is an active ingredient used in the manufacturing of various pharmaceutical dosage forms, including tablets, capsules, topical creams, and gels.

Usage: The dosage and administration of Troxerutin depend on the specific formulation and the patient's condition. Dosages may vary according to the severity of the condition and the product's specific instructions provided by healthcare professionals.

Side Effects: Troxerutin is generally considered safe when used as directed. However, some individuals may experience mild side effects such as gastrointestinal disturbances or allergic reactions. It's essential to consult a healthcare professional for guidance before using products containing Troxerutin, especially if you have any underlying health conditions or are taking other medications.

Availability: Troxerutin powder as an API is primarily available to pharmaceutical manufacturers and compounding pharmacies for the production of medications and supplements targeting venous disorders.

 

Inspection Item

 

standard

 

Inspection consequence

 

conclusion

 

Characteristics

 

yellowsh-green crystalline powder hygroscopic.

 

Yellowsh crystalline powder,

hygroscopic.

 

 

Conforms to regulation

 

 

 

Identification

A Infrared absorption CRS

BResults the principal peak in the

chromatogram obtained with the test

solution is similar in position and size to

the principal peak in the chromatogram

obtained with the   reference

solution(a)

 

B Results the principal peak in the

chromatogram obtained with the test

solution is similar in position and size

to the principal peak in the

chromatogram obtained with the

reference solution(a)

 

 

 

 

 

 

Conforms to regulation

 

 

 

 

 

 

 

 

 

TE

ST

S

 

 

 

 

composition

 

Principal peak:minimum 80 per cent  

Except for I peak:which can be

maximum 10 per cent ;Any other

peak:for each peak, maximum 5 per

cent

 

Principal peak:87per centExcept for

I peak:which can be 7 per cent  Any

other peak:for each peak, 3per cent

 

 

 

Conforms to regulation

 

Ethylene oxide

maximums 1ppm

 

Conforms /to regulation

 

Conforms to regulation

 

Loss on drying

maximums 5 per cent

1.5%

 

Conforms to regulation

 

Sulphated ash

maximums 0.4 per cent

0.15%

 

Conforms to regulation

 

Heavy metals

 

maximums 20ppm

 

Conforms to regulation

 

Conforms to regulation

 

Cadmium

 

maximums 1 PPM

 

Conforms to regulation

 

Conforms to regulation

 

Lead

 

maximums 3 PPM

 

Conforms to regulation

 

Conforms to regulation

 

Mercury

 

maximums 0. 1 PPM

 

Conforms to regulation

 

Conforms to regulation

 

Arsenic

 

maximums 1 PPM

 

Conforms to regulation

 

Conforms to regulation

 

 

 

Total plate count

 

Less than 1000CFU/G

 

Less than 1000cfu/g

 

Conforms to regulation

 

Yeast&Mould

 

Less than 100CFU/G

 

Less than 100cfu/g

 

Conforms to regulation

 

E.coli

 

Absent

 

Absent

 

Conforms to regulation

 P.aeruginosa

 

Absent

 

Absent

 

Conforms to regulation

 

Methanol

maximums 0.3 per cent

0.015%

 

Conforms to regulation

 

assay(dried substance)

95.0%105.0%    95.0  percent to105.0 percent

98.5%

 

Conforms to regulation

 

conclusion

 

based on    EP     Inspection Conforms to regulation

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