1.What is Upadacitinib?

Upadacitinib is a medication that selectively inhibits Janus kinases (JAK) within the immune system, primarily by targeting the JAK1 and JAK3 subtypes, thereby mitigating immune responses. Its role in the immune system is mainly reflected in its anti-inflammatory, immunomodulatory, and antiviral effects.

 

2.How it Works?

Upadacitinib is a novel oral JAK1/JAK2 inhibitor. It exerts its anti-inflammatory effects by blocking the interleukin-6 receptor (IL-6R) and interferon-gamma receptor (IFN-γR), thereby reducing the production of inflammatory cytokines.

3.Benefits and Uses

1. Atopic Dermatitis: This is a common chronic inflammatory skin disease with an unclear specific etiology, potentially related to genetic, environmental, and immune abnormalities. Patients may experience symptoms such as dry skin, itching, and pain. Upadacitinib extended-release tablets, as an immunosuppressant, play a leading role in the release of pro-inflammatory cytokines, helping to eliminate inflammatory responses within the body and promoting recovery.

2. Psoriatic Arthritis: This is a chronic inflammatory joint disease primarily associated with genetic and infectious factors. Patients may experience symptoms such as joint pain, stiffness, and deformity. After entering the body, Upadacitinib extended-release tablets can mediate cytokine signaling through its own pairing, blocking the phosphorylation and activation of STAT, thereby exerting therapeutic effects. It is suitable for adult patients with active psoriatic arthritis who are intolerant to other treatments.

3. Rheumatoid Arthritis: This is a chronic immune disease mainly related to genetic and autoimmune factors. Patients may experience symptoms such as morning stiffness, joint pain, and joint swelling. Upadacitinib extended-release tablets can influence cellular immune function, activate signal transduction factors, and promote the excretion of inflammatory cytokines.

4. Ulcerative Colitis: The specific cause is still unclear, with patients primarily experiencing symptoms such as diarrhea, bloody stools, and abdominal pain. It is suitable for patients with moderate to severe active ulcerative colitis.

4.Q&A

Q:Does the company accept sample orders?

A:Yes, our company accepts sample orders.

Q:What is the minimum order quantity for the company?

A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.

Q:How to ensure the quality of goods?

A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.

Q:Can we see the product quality before the order is shipped?

A:Of course, we always provide a relative Batach (s) 'COA before shipping.

Q:How will you deliver the goods?

A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.

5.Factory View